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KMID : 0359920100290050638
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Korean Journal of Nephrology
2010 Volume.29 No. 5 p.638 ~ p.643
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A Case of AA Amyloidosis Treated with Infliximab
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Kim Da-Ham
Park Kyeong-Hye
Lee Su-Hwan
Hyun Shin-Young
Kie Jeong-Hae
Kang Ea-Wha
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Abstract
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AA amyloidosis is one of the most significant complications of rheumatoid arthritis characterized by the deposition of amyloid A (AA) in multiple organs and tissues in the body. This disorder displays variable clinical symptoms depending upon the involved organ and a diagnosis is rendered through a biopsy of the affected organ, followed by staining using Congo-red which reveals an apple-green birefringence. Fundamental disease control is critical in the treatment of AA amyloidosis. Anti-tumor necrosis factor alpha (anti TNF-α) agents are promising in inducing clinical remission by suppressing systemic inflammation in AA amyloidosis. We report a case of AA amyloidosis in a 71 year old woman with rheumatoid arthritis that responded well to infliximab therapy.
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KEYWORD
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Amyloidosis, Rheumatoid arthritis, Infliximab
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